CYBERMED NEWS - Higher Medical Scientifc Information and Research

Drugs

  • CHMP recommends EU marketing approval of ten drugs

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    The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) recommended seven medicines for approval, including two orphan medicines, plus three generics at its November 2017 meeting.

  • 'Independent' researchers have shares in drug companies they're testing

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    Independent drug trials aren't always quite so independent. Researchers are still not revealing the pay-outs they're getting from drug companies whose drugs they are testing—and in some cases they even have shares in the company.

    Around a third of researchers are not disclosing their financial conflicts of interest despite the enormous pressure from medical journals for transparency in clinical trials.

    Some researchers get speaking fees, others receive 'research grants' and others hold shares in the drug company whose drug they are reviewing, but which they are not revealing in their research that is presented as being independent.

  • 'Mind tactics' on doctors are tripling opioid prescribing

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    Tactics from the world of behavioural science are being used on doctors to encourage them to prescribe more drugs, such as statins, opioids and the flu vaccine.

    Doctors who are exposed to techniques such as 'nudges' triple the number of prescriptions they write out, a new study has discovered.

    Nudges and other techniques from the world of behavioural science are being built into software systems that doctors access when they are treating patients. Two common 'nudges' are reminders at the point when the doctor decides on the next steps and later when their prescribing levels are compared to those of other doctors.

    The techniques are tripling the number of prescriptions being written, say researchers from the University of Pennsylvania's School of Medicine.

  • 'New opioid' painkiller scandal looms

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    The opioid addiction scandal may be triggering the misuse of another painkiller. Prescriptions for gabapentinoids have doubled in the last few years as the opioid epidemic has been making the headlines.

    Gabapentinoids—which include gabapentin and pregabalin—are licensed as anti-seizure and nerve pain medications, but around 95 percent of prescriptions are 'off-label', meaning they are given to treat other health problems, such as migraine and fibromyalgia.

  • 35 per cent of adverse reactions to drugs not being reported in studies

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    Medicine is even more dangerous than we all thought. Around one-third of serious side effects to drugs and surgery are not being recorded in medical trials, a major review has discovered.

    Around 35 per cent of research studies that investigate the safety and effectiveness of drugs and surgery are not properly reporting on side effects and adverse reactions.

  • 80% of older hospital patients discharged with wrong drugs

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    Around four out of five older patients are being discharged from hospital with 'inappropriate' medication—such as the wrong drug—that is causing a life-changing reaction or even death.

    A prescribing error is often responsible for the death of an elderly patient and those who suffer a serious reaction will be admitted to hospital at least three times before they recover, a new study has discovered.

    Around half of older patients die after they were given a wrong drug or weren't given the drug they needed, say researchers at the Aberdeen Royal Infirmary in Scotland.

    They analysed the records of 259 patients—with an average age of 77—who had been discharged from hospital. They were given a total of 2,411 medications, which means many had nine or more prescriptions, and 59 per cent were given 'inappropriate medications', such as a wrong drug, and nearly 70 per cent weren't given the drug they were supposed to have.

  • Alzheimer's drugs don't work, but keeping your heart healthy just might

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    The only drug licensed to prevent Alzheimer's disease doesn't work. Instead, staying mentally stimulated, avoiding stress and keeping your cardiovascular system healthy are far more effective.

  • Antibiotics block our immune system from fighting the bugs

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    Antibiotics can be life-saving drugs—but they also weaken our immune system and lower our defences when we need to fight off infections.

    The drugs interfere with 'first-line' immune cells—known as neutrophils—and they also weaken the intestinal barrier which stops invading bugs. As a result, we're much more susceptible to 'severe infection', said Koji Watanabe from the University of Virginia School of Medicine.

  • Antibiotics can make flu deadly

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    Antibiotics aren't great for our gut, as we all know—but now researchers have discovered the drugs interfere with signals from the gut that make our lungs more vulnerable to a serious, even life-threatening, form of flu.

    Gut bacteria act as a first-line defence system for the lungs—and it's the lining of the lungs, and not the immune system as everyone assumed, that receive signals from the bacteria.

  • Antibiotics raise risk of heart disease and cancer

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    Although antibiotics can be life-saving drugs, they also raise the risk for a range of other serious chronic conditions, including heart disease and some cancers, new research has found.

    This is because antibiotics destroy the 'good' bacteria in the gut that protect against infections and inflammation, and inflammation is the key to many chronic diseases, from arthritis, heart problems and cancer.

    Although medicine accepts that over-use of antibiotics leads to resistance and 'super bugs', it can also be the gateway drug to most of the chronic diseases that afflict the West.

  • Antibiotics raise risk of heart disease and stroke

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    Antibiotics aren't only bringing closer the era of the super-bug—they also increase your chances of heart attack and stroke if you take them long enough.

    People taking the drugs for two months or longer were 32 per cent more likely to develop cardiovascular disease, say researchers who reviewed a study involving around 36,500 women.

  • Antidepressants deaden empathy for others in pain

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    Antidepressants don't only deaden feelings of depression—they also reduce empathy for others who are in pain.

    The drugs—and mainly the SSRI (selective serotonin reuptake inhibitor) antidepressants—lower "the emotional impact of negative events", say researchers from the University of Vienna.

  • Antidepressants increase risk of premature death by 33%

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    Antidepressants don't just increase the risk of suicide—people taking the drugs are 33 per cent more likely to die from any cause, including heart attack, stroke and even organ failure.

    Many of the body's organs, including the heart, kidneys, lungs and liver, depend on serotonin, a chemical that the drugs block to treat depression.

  • Antimalaria drugs are not curing COVID-19, researchers say

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    Antimalarial drugs have been touted as an answer to COVID-19 infection, and even President Trump has described them as 'a game-changer'—but they can cause life-threatening heart problems.

    A new study into chloroquine was stopped suddenly after two patients died from an irregular heart rate, known as ventricular tachycardia. Researchers from Brazil had planned on a major trial involving 440 people infected with COVID-19, but started to see very worrying reactions to high doses of the drug among the first 81 patients who were being tested.

  • Big Pharma has ‘bought Congress’, says FDA chairman

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    Big Pharma has ‘bought Congress’, says FDA chairman image

    Presidential election promises of an overhaul of drug policy and pricing will come to nothing—because Congress has been bought by Big Pharma, says a leading light at the US's Food and Drug Administration (FDA).

    Former House speaker Raul Ryan received $222,070 in drug company donations, with most of it being paid by drug giant Merck, and Democrat presidential hopeful Beta O'Rourke was given $171,255, according to Open Secrets, which has ranked the 20 members of the House and Senate who received the most money from the drugs industry during the 2017-18 election cycle. In all, the pharmaceutical industry paid out more than $100m to Congress and presidential hopefuls.

  • Big Pharma suppresses the evidence on dangerous or useless drugs

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    Pharmaceutical companies are deliberately misleading health agencies and governments by suppressing research that reveals a drug doesn't work or is dangerous. At least half of all medical trials are never published.

    In one example, governments were hoodwinked into stockpiling Tamiflu during the swine flu scare of 2009—but hadn't seen unpublished studies that found it wasn't effective. Around 80 per cent of the studies into the drug—that showed it didn't prevent complications after someone contracted flu—were either never published or hadn't been independently reviewed first.

  • Big Pharma takes tighter control of world's leading 'independent' health websites

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    Many of the world's major medical websites are now owned directly—or indirectly—by the pharmaceutical industry, although this is hidden from consumers searching for independent health advice.

    WebMD, RxList, MedicineNet and Medscape are the latest to forge ever-closer ties to the pharmaceutical industry after they were purchased by private investment firm KKR (Kohlberg, Kravis, Roberts & Co). The takeover will be finalised by the end of this year.

  • Blood pressure drugs damage the kidneys (when they're supposed to protect them)

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    Drugs for treating high blood pressure—such as the ACE (angiotensin converting enzyme) inhibitors—can damage the kidneys, new research has discovered. Ironically, the drugs are supposed to protect the organs.

    The greatest risk is when several different types of the drugs, known as antihypertensives, are taken in combination, and, in particular, the drugs that regulate the hormone, renin, which affects blood pressure levels.

  • Blood pressure drugs make COVID-19 virus lethal

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    Blood pressure medication is one factor that's making the COVID-19 virus lethal. The drugs increase the chances of viral pneumonia and fatal respiratory failure, new research has discovered.

    People who are taking an ACE inhibitor or an ARB drug for heart problems should stay at home and not meet up with people, say researchers from Louisiana State University.

    Dr Malcolm Kendrick, a UK GP, estimates that people taking one of the drugs are four times more likely to die from the virus.

  • Blood pressure meds cause dangerous intestinal problems

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    A common blood pressure drug can cause diverticulosis, a bowel problem that affects many elderly people.

    Calcium-channel blockers are antihypertensives—they keep high blood pressure under control—that also raise the risk of diverticulosis, a bowel problem that causes small bulges or pouches in the intestine. Left untreated, it can lead to diverticulitis, when the pouches become inflamed.

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