CYBERMED NEWS - Higher Medical Scientifc Information and Research

Anti-acid drugs

  • Lansoprazole and carbonic anhydrase IX inhibitors sinergize against human melanoma cells

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    Lansoprazole and carbonic anhydrase IX inhibitors sinergize against human melanoma cells

     

     

    Abstract

    Context: Proton Pump Inhibitors (PPIs) reduce tumor acidity and therefore resistance of tumors to drugs. Carbonic Anhydrase IX (CA IX) inhibitors have proven to be effective against tumors, while tumor acidity might impair their full effectiveness.

    Objective: To analyze the effect of PPI/CA IX inhibitors combined treatment against human melanoma cells.

    Methods: The combination of Lansoprazole (LAN) and CA IX inhibitors (FC9-399A and S4) has been investigated in terms of cell proliferation inhibition and cell death in human melanoma cells.

    Results: The combination of these inhibitors was more effective than the single treatments in both inhibiting cell proliferation and in inducing cell death in human melanoma cells.

    Discussion: These results represent the first successful attempt in combining two different proton exchanger inhibitors.

    Conclusion: This is the first evidence on the effectiveness of a new approach against tumors based on the combination of PPI and CA IX inhibitors, thus providing an alternative strategy against tumors.

     

    http://www.tandfonline.com/doi/full/10.1080/14756366.2016.1177525

     

  • Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect

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    Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect

     

    Abstract

    CONTEXT:

    Tumor acidity represents a major cause of chemoresistance. Proton pump inhibitors (PPIs) can neutralize tumor acidity, sensitizing cancer cells to chemotherapy.

    OBJECTIVE:

    To compare the anti-tumor efficacy of different PPIs in vitro and in vivo.

    MATERIALS AND METHODS:

    In vitro experiments PPIs anti-tumor efficacy in terms of cell proliferation and cell death/apoptosis/necrosis evaluation were performed. In vivo PPIs efficacy experiments were carried out using melanoma xenograft model in SCID mice.

    RESULTS:

    Lansoprazole showed higher anti-tumor effect when compared to the other PPIs. The lansoprazole effect lasted even upon drug removal from the cell culture medium and it was independent from the lipophilicity of the PPIs formulation.

    DISCUSSION:

    These PPIs have shown different anti-tumoral efficacy, and the most effective at low dose was lansoprazole.

    CONCLUSION:

    The possibility to contrast tumor acidity by off-label using PPIs opens a new field of oncology investigation.

     

    https://www.ncbi.nlm.nih.gov/pubmed/26018420

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