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Effect of Modified Alkaline Supplementation on Syngenic Melanoma Growth in CB57/BL Mice

Abstract

Tumor extracellular acidity is a hallmark of malignant cancers. Thus, in this study we evaluated the effects of the oral administration of a commercially available water alkalizer (Basenpulver®) (BP) on tumor growth in a syngenic melanoma mouse model. The alkalizer was administered daily by oral gavage starting one week after tumor implantation in CB57/BL mice. Tumors were calipered and their acidity measured by in vivo MRI guided ³¹P MRS. Furthermore, urine pH was monitored for potential metabolic alkalosis. BP administration significantly reduced melanoma growth in mice; the optimal dose in terms of tolerability and efficacy was 8 g/l (p< 0.05). The in vivo results were supported by in vitro experiments, wherein BP-treated human and murine melanoma cell cultures exhibited a dose-dependent inhibition of tumor cell growth. This investigation provides the first proof of concept that systemic buffering can improve tumor control by itself and that this approach may represent a new strategy in prevention and/or treatment of cancers.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159763

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Rapporto di equilibrio tra le sostanze acide e quelle basiche nel corpo. Il corpo umano nei processi metabolici produce numerose sostanze acide, come a esempio l’anidride carbonica. La condizione di equilibrio, raggiunta per un valore di pH pari a 7,35, è mantenuta dal corpo attraverso l’utilizzo di sostanze tampone (come a esempio bicarbonati e fosfati) e attraverso l’eliminazione delle sostanze nocive (come avviene con l’anidride carbonica eliminata dai polmoni).